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Abstract #8755 Published in IGR 5-1
Incidence of glaucoma in patients of collagen disease and the implication of long-term systemic corticosteroid
Nagayama M; Tamura N; Umeda T; Ohtsuki H; Yamaguchi KI; Miyawaki SJapanese Journal of Clinical Ophthalmology 2003; 57: 119-123
The authors evaluated 244 patients of collagen disease regarding the presence of various types of glaucoma. Normal-tension glaucoma (NTG) was present in four cases (1.6%) and open-angle glaucoma in three(1.2%). Of 172 cases that had received systemic corticosteroid for one year or longer, corticosteroid appeared to be the cause of raised intraocular pressure (IOP) in six cases (3.5%). The daily dose of corticosteroid averaged 7.5 ± 2.25 mg of prednisolone equivalent in the group of raised IOP, and 7.5 ± 2.9 mg in that of non-raised IOP. There was no significant difference between the two groups. The duration of corticosteroid treatment averaged 11 ± 9.9 years in the former and 11 ± 6.5 years in the latter. There was no significant difference between the two groups. Patients with Sjoegren disease had no NTG, but it was present in 3% of patients of chronic rheumatic arthritis and scleroderma. These findings show that the incidence of NTG is the same in patients with collagen disease and in the normal population. Patients under long-term corticosteroid have a low risk of raised IOP when the daily dose is less than 10 mg of prednisolone equivalent.LA: Japanese
Dr. M. Nagayama, Department of Ophthalmology, Okayama University Graduate School of Medicine/Dentistry, 2-5-1 Shikata-cho, Okayama-shi, 700-0914, Japan
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
