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Abstract #8440 Published in IGR 5-1
Observation of choroidal circulation using index of erythrocytic velocity
Isono H; Kishi S; Kimura Y; Hagiwara N; Konishi N; Fujii HArchives of Ophthalmology 2003; 121: 225-231
OBJECTIVE: To describe a noninvasive method of visualizing choroidal circulation by means of erythrocytic velocity. METHODS: Laser speckle flowgraphy (LSFG) and indocyanine green (ICG) angiography were performed in nine volunteers. LSFG measures the quantitative relative velocity index of erythrocytes (normalized blur (NB) value) in retinal and choroidal vessels. The authors averaged NB values from three pulsations and made composite 1.5-mm-square NB maps during one pulsation. By overlapping five adjacent maps, they created a panoramic 3.0-mm-square NB map of the posterior pole. The vascular patterns of the panoramic map and ICG angiography were compared. To determine the influence of retinal vessels, the authors induced branch retinal artery occlusion in two monkey eyes and compared the panoramic maps before and after occlusion. RESULTS: The NB map showed pulsatile blood flow in choroidal and retinal vessels. Vascular pattern contrast was improved in the NB map. Choroidal vessels in ICG angiography corresponded to those in the NB map. Vascular patterns in the map changed little before and after branch retinal artery occlusion. CONCLUSIONS: LSFG noninvasively visualized the hemodynamics of choroidal circulation, and the vascular pattern, which is mainly choroidal in origin, was comparable with that of ICG angiography. CLINICAL RELEVANCE: LSFG may be used to evaluate choroidal hemodynamics in various choroidal diseases.
Dr. H. Isono, Department of Ophthalmology, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan. isono@tohgoku.or.jp
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)