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Abstract #8673 Published in IGR 5-1
Development of in situ thermosensitive drug vehicles for glaucoma therapy
Hsiue GH; Chang RW; Wang CH; Lee SHBiomaterials 2003; 24: 2423-2430
The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. A thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced a polymeric eye drop containing the drug epinephrine and was a clear solution at room temperature which became a soft film after contacting the surface of cornea. The drug entrapped within the tangled polymer chains was therefore released progressively after topical application. Evaluation of the drug release responded as a function of crosslinking density and PHEMA macromer contents. The in vivo studies indicated that the intraocular pressure (IOP)-lowering effect for a polymeric eye drop lasted for 26 hours, which is significantly better than the effect of traditional eye drops (eight hours). Hence, these investigations successfully prove that a thermosensitive polymeric eye drop with the possibility of controlled drug release exhibits a greater potential for glaucoma therapy.
Dr. G.H. Hsiue, Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan. ghhsiue@che.nthu.edu.tw
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
